Journal article
Tracing the environmental footprint of the Burkholderia pseudomallei lipopolysaccharide genotypes in the tropical “Top End” of the Northern Territory, Australia
JR Webb, A Rachlin, V Rigas, DS Sarovich, EP Price, M Kaestli, LM Ward, M Mayo, BJ Currie
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2019
Abstract
The Tier 1 select agent Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a high mortality disease. Variably present genetic markers used to elucidate strain origin, relatedness and virulence in B. pseudomallei include the Burkholderia intracellular motility factor A (bimA) and filamentous hemagglutinin 3 (fhaB3) gene variants. Three lipopolysaccharide (LPS) O-antigen types in B. pseudomallei have been described, which vary in proportion between Australian and Asian isolates. However, it remains unknown if these LPS types can be used as genetic markers for geospatial analysis within a contiguous melioidosis-endemic region. Using a combination of whole-genome se..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The research was funded under the Australian National Health and Medical Research Council grant numbers 1046812, 1098337, and 1131932 (The HOT NORTH initiative). DSS and EPP are supported by Advance Queensland Fellowships (AQRF13016-17RD2 and AQIRF0362018, respectively). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.